Wicked Good Deal – 50% OFF all products
Upgrade your nucleic acid delivery system today and save big!
Lipid nanoparticle (LNP) formulations may be undermining your siRNA/mRNA delivery potential, as they often come with significant challenges: inconsistent reproducibility with microfluidic cartridges, poor encapsulation efficiency, limited extrahepatic delivery and high cost. RJH reagents Leu-Fect and ALL-Fect solve these pain points while adding superior biodistribution, sustained cargo retention, and improved efficacy over standard LNP formulations. Simple formulation steps facilitates rapid screening and ensures reproducible results.
Superior Extrahepatic Tropism
Unlike traditional LNPs that get trapped in the liver, RJH reagents bypass the hepatic barrier and reach essential targets such as bone marrow.
Leu‑Fect-formulated LPNPs drive potent extrahepatic siRNA delivery, with elevated siRNA levels in bone marrow, spleen, and lung 24 hours after IV dosing in BALB/c mice (n=5).
Sustained Therapeutic Retention
Why inject constantly when your delivery vehicle can retain the payload? While LNP-delivered siRNAs are cleared rapidly from the body, lipopolymers protect and retain therapeutic nucleic acids in target tissues for over a week after a single injection.
NCG mice (n=5) treated with Leu-Fect/siRNA maintained robust, therapeutic siRNA levels in liver, bone marrow, spleen, and lung after 7 days. siRNA levels in LNP-treated mice were almost undetectable in the same timeframe.
Better and Sustained Efficacy
Optimizing knockdown effectiveness together with maintaining prolonged cytotoxicity is crucial for cancer therapeutics. ALL-Fect, the RJH reagent, is perfectly suited for this task.
In A549 cells (pulmonary epithelial cells) treated with 60 nM siRNA, RJH reagent delivery of STAT5- or SURVIVIN-targeting siRNAs reduced cell viability to 35-50% on day 3 and maintained this low viability through 9 days. Standard LNP formulations (LNP1 and LNP2) showed poor efficacy.
*Offer valid through the end of October/2026. To claim your discount or discuss a custom formulation, simply reply to info@rjhbiosciences.com.
About RJH Biosciences
RJH Biosciences specializes in lipopolymer-based transfection reagents for efficient sgRNA, siRNA, mRNA, and pDNA delivery across a wide range of biological systems. Our platforms are optimized for high-throughput screening, functional genomics, and RNA interference (RNAi) applications, enabling reliable gene modulation in cell lines, primary cells, and in vivo models.
Get personalized advice from RJH on the best transfection info@rjhbiosciences.com or visit www.rjhbiosciences.com
